Cannabinoid Receptor (CB1) Plays Crucial Role in Alzheimers Disease

Cannabinoid Receptor (CB1)  Plays Crucial Role in Alzheimers Disease

As you are reading this, or not, you are forming substances that will give you dementia. You are forming beta amyloid inside the neurons of some of the more important parts of your brain responsible for memory, learning cognition, football scores etc. Most of you, however, toss it out of those cells so that you can now remember why you are standing half way up the stairs with a spatula in your hand. But then comes a day when you start to no longer clear those nasty wastes and they start to build up in your neurons. As they do this, they induce a toxic inflammation (neuro inflammation never a good thing) that leads to impaired cognition and ultimately to the demise of that neuron. Neuroinflammation causes memory decline and other conditions associated with aging. Also associated with aging is a decline in our protective endocannabinoid system (ECS) that includes a lack of receptors and our own natural ligands that activate them. There are other separate and yet related aspects of dementia that involve interesting sounding terms like tau hyperphosphorylation that are also addressed by our ECS. (If you don’t know what ECS is then please take five minutes and review it as it is the basis to understanding why we use cannabis as medicine.)
 
It appears that cannabis might well play a significant role in that at least two cannabinoids, THC and CBD (if not more cannabinoids and terpenes) do the following: 
THC 
1. slows production of beta amyloid
2. stimulates removal of beta amyloid from the cell
3. blocks neuro inflammation
4. decreases eicosands, and who wants more of something that is that difficult to spell
5. is neuroprotective
 
It doesn’t appear to take a high dose of THC to do these things. In fact, an ultra low dose reversed age-dependent cognitive impairment in old mice, rendering their memories similar to those of a young mouse. “Ahh, now I remember what that cat is about to do.”
 
Meanwhile CBD:
1. decreases neuro inflammation
2. also expedites removal of beta amyloid from the cell
3. reduces beta amyloid induced hyperphosphorylation of tau (Though this sounds like a Tibetan indie flick, it is actually an important aspect of developing Alzheimers. It is also cool to repeat that sentence on a date.) 
4. acts on the actual nucleus of the nerve cell to suppress activation of pro inflammatory signaling via a receptor known as PPAR gamma
5. acts in the neighboring microglial cells to reduce inflammation
 
If you can now close your eyes and recite this article by memory then go and read an Archie cartoon book; but if not, then you may consider learning more about cannabis’ role in dementia. Plena is also working at developing a supplement that will be useful for dementia.... though I can’t recall what it is. 
 
Refrence
 
Dr. David Hepburn

Plena Global supplies the world’s medical cannabis needs via cannabis grow operations to provide licensed distributors with a clean supply of GACP flower and GMP extracts